Comparison of diffusion‐weighted imaging and [123I]IBZM‐SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's disease
Identifieur interne : 003D63 ( Main/Exploration ); précédent : 003D62; suivant : 003D64Comparison of diffusion‐weighted imaging and [123I]IBZM‐SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's disease
Auteurs : Klaus Seppi [Autriche] ; Michael F. H. Schocke [Autriche] ; Eveline Donnemiller [Autriche] ; Regina Esterhammer [Autriche] ; Christian Kremser [Autriche] ; Christoph Scherfler [Autriche] ; Anja Diem [Autriche] ; Werner Jaschke [Autriche] ; Gregor K. Wenning [Autriche] ; Werner Poewe [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-12.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Basal Ganglia (blood supply), Benzamides, Comparative study, Contrast Media, Corpus Striatum (blood supply), Cross-Sectional Studies, Diffusion Magnetic Resonance Imaging, Diffusion imaging, Diffusion‐weighted imaging (DWI), Follow-Up Studies, Frontal Lobe (blood supply), Human, Humans, Middle Aged, Multiple System Atrophy (complications), Multiple System Atrophy (diagnosis), Multiple System Atrophy (radionuclide imaging), Multiple system atrophy, Multiple system atrophy (MSA), Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease (PD), Photon, Predictive Value of Tests, Pyrrolidines, Sensitivity and Specificity, Single photon emission tomography, Tomography, Emission-Computed, Single-Photon, [123I]IBZM‐SPECT, dopamine D2 receptors.
- MESH :
- chemical : Benzamides, Contrast Media, Pyrrolidines.
- blood supply : Basal Ganglia, Corpus Striatum, Frontal Lobe.
- complications : Multiple System Atrophy, Parkinson Disease.
- diagnosis : Multiple System Atrophy, Parkinson Disease.
- radionuclide imaging : Multiple System Atrophy, Parkinson Disease.
- Cross-Sectional Studies, Diffusion Magnetic Resonance Imaging, Follow-Up Studies, Humans, Middle Aged, Predictive Value of Tests, Sensitivity and Specificity, Tomography, Emission-Computed, Single-Photon.
Abstract
Both dopamine D2 receptor (D2R) binding single‐photon emission computed tomography (SPECT) with [123I]iodobenzamide (IBZM) and diffusion‐weighted imaging (DWI) have been shown to contribute to the differential diagnosis of patients with the Parkinson variant of multiple system atrophy (MSA‐P) and Parkinson's disease (PD). We aimed to compare these two routinely available functional imaging modalities in differentiating patients with MSA‐P from PD. For this purpose, results obtained by DWI and IBZM‐SPECT were intraindividually compared in a cross‐sectional study of 15 MSA‐P and 17 PD patients matched for age and disease duration. The activity ratios of striatal to frontal cortex uptake (S/FC ratio) were used as a semiquantitative measure of the relative density of basal ganglia dopamine receptors labeled by IBZM. Regional apparent diffusion coefficients (rADC) were determined in the striatum. MSA‐P patients had significantly lower S/FC ratios and significantly higher striatal rADCs than both PD patients and healthy volunteers. There were no significant differences in S/FC ratios and striatal rADC between PD patients and healthy volunteers. Sensitivity of IBZM‐SPECT versus DWI for the differentiation of MSA‐P from PD was 80% versus 93%, specificity 71% versus 100%, the predictive accuracy 75% versus 97%, the positive predictive value 71% versus 100%, and the negative predictive value 80% versus 94%. Striatal rADCs had a significant higher overall predictive accuracy than D2R binding with IBZM. In summary, our data suggest that DWI may be more accurate compared to IBZM‐SPECT in the differential diagnosis of MSA‐P versus PD. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20229
Affiliations:
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Wenning</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University of Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University of Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-12">2004-12</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1438">1438</biblScope><biblScope unit="page" to="1445">1445</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B2F18CE15F75A215978EF7B642F881D37A6ED584</idno><idno type="DOI">10.1002/mds.20229</idno><idno type="ArticleID">MDS20229</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal Ganglia (blood supply)</term><term>Benzamides</term><term>Comparative study</term><term>Contrast Media</term><term>Corpus Striatum (blood supply)</term><term>Cross-Sectional Studies</term><term>Diffusion Magnetic Resonance Imaging</term><term>Diffusion imaging</term><term>Diffusion‐weighted imaging (DWI)</term><term>Follow-Up Studies</term><term>Frontal Lobe (blood supply)</term><term>Human</term><term>Humans</term><term>Middle Aged</term><term>Multiple System Atrophy (complications)</term><term>Multiple System Atrophy (diagnosis)</term><term>Multiple System Atrophy (radionuclide imaging)</term><term>Multiple system atrophy</term><term>Multiple system atrophy (MSA)</term><term>Nervous system diseases</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson disease</term><term>Parkinson's disease (PD)</term><term>Photon</term><term>Predictive Value of Tests</term><term>Pyrrolidines</term><term>Sensitivity and Specificity</term><term>Single photon emission tomography</term><term>Tomography, Emission-Computed, Single-Photon</term><term>[123I]IBZM‐SPECT</term><term>dopamine D2 receptors</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Benzamides</term><term>Contrast Media</term><term>Pyrrolidines</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Basal Ganglia</term><term>Corpus Striatum</term><term>Frontal Lobe</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cross-Sectional Studies</term><term>Diffusion Magnetic Resonance Imaging</term><term>Follow-Up Studies</term><term>Humans</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Sensitivity and Specificity</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term><term>Etude comparative</term><term>Homme</term><term>Imagerie de diffusion</term><term>Parkinson maladie</term><term>Photon</term><term>Système nerveux pathologie</term><term>Tomoscintigraphie émission monophotonique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Both dopamine D2 receptor (D2R) binding single‐photon emission computed tomography (SPECT) with [123I]iodobenzamide (IBZM) and diffusion‐weighted imaging (DWI) have been shown to contribute to the differential diagnosis of patients with the Parkinson variant of multiple system atrophy (MSA‐P) and Parkinson's disease (PD). We aimed to compare these two routinely available functional imaging modalities in differentiating patients with MSA‐P from PD. For this purpose, results obtained by DWI and IBZM‐SPECT were intraindividually compared in a cross‐sectional study of 15 MSA‐P and 17 PD patients matched for age and disease duration. The activity ratios of striatal to frontal cortex uptake (S/FC ratio) were used as a semiquantitative measure of the relative density of basal ganglia dopamine receptors labeled by IBZM. Regional apparent diffusion coefficients (rADC) were determined in the striatum. MSA‐P patients had significantly lower S/FC ratios and significantly higher striatal rADCs than both PD patients and healthy volunteers. There were no significant differences in S/FC ratios and striatal rADC between PD patients and healthy volunteers. Sensitivity of IBZM‐SPECT versus DWI for the differentiation of MSA‐P from PD was 80% versus 93%, specificity 71% versus 100%, the predictive accuracy 75% versus 97%, the positive predictive value 71% versus 100%, and the negative predictive value 80% versus 94%. Striatal rADCs had a significant higher overall predictive accuracy than D2R binding with IBZM. In summary, our data suggest that DWI may be more accurate compared to IBZM‐SPECT in the differential diagnosis of MSA‐P versus PD. © 2004 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></noRegion><name sortKey="Diem, Anja" sort="Diem, Anja" uniqKey="Diem A" first="Anja" last="Diem">Anja Diem</name><name sortKey="Donnemiller, Eveline" sort="Donnemiller, Eveline" uniqKey="Donnemiller E" first="Eveline" last="Donnemiller">Eveline Donnemiller</name><name sortKey="Esterhammer, Regina" sort="Esterhammer, Regina" uniqKey="Esterhammer R" first="Regina" last="Esterhammer">Regina Esterhammer</name><name sortKey="Jaschke, Werner" sort="Jaschke, Werner" uniqKey="Jaschke W" first="Werner" last="Jaschke">Werner Jaschke</name><name sortKey="Kremser, Christian" sort="Kremser, Christian" uniqKey="Kremser C" first="Christian" last="Kremser">Christian Kremser</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><name sortKey="Schocke, Michael F H" sort="Schocke, Michael F H" uniqKey="Schocke M" first="Michael F. H." last="Schocke">Michael F. H. Schocke</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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